Clotrimazole instructions for use. Clotrimazole ointment - instructions for use for men and women, from which the drug Clotrimazole helps

The drug clotrimazole has various forms of release. Candles, solutions, creams, gels and ointments. The ointment form is the most popular.

Compound

Ointment contains clotrimazole, in the amount of 1 gram.

In addition to it, the composition includes excipients:

• propylene glycol;
• polyethylene oxide 400;
• polyethylene oxide 1500;
• methyl parahydroxybenzoate or methyl paraben.

Operating principles

is a substance from the group of imidazole derivatives. It acts on fungal organisms as a poison, disrupting their vital processes. Clotrimazole inhibits the synthesis of ergosterol, a structural component of fungal cells, which leads to their gradual destruction.

Since the ointment is poorly absorbed, the substance accumulates in the upper layers of the skin, which leads to an increase in the detrimental effect on pathogenic fungal organisms.

In sufficiently high doses, the drug also has an additional toxic effect on fungal cells, increasing the concentration of hydrogen peroxide in them, and accelerating the process of their destruction.

The drug is active against the following pathogenic fungi:

• dermatophytes;
• yeast fungi;
• moldy fungi;
• causative agents of multi-colored lichen and erythrasma.

It has a weak antimicrobial effect against some gram-positive and gram-negative bacteria.

Clotrimazole ointment is absorbed into the skin and mucous membranes. The substance is concentrated in the epidermis and in the keratin of the nails, almost not penetrating into the lower layers of the skin and practically not getting into the bloodstream.

Indications for use

The drug is used to treat various diseases of the legs, mucous membranes, skin caused by fungi:

• thrush;
• stomatitis;
• genital candidiasis complicated by trichomoniasis;
• superficial candidiasis;
• dermatomycosis;
• paronychia;
• dermatophytosis;
• erythrasma;
• mycoses complicated by infection of pyogenic cocci.

Ways to use Clotrimazole

First of all, you need to prepare the affected area:

• Clean it with soap and water and wipe dry;
• Soap should be soft, such as baby soap, because alkaline environment reduces the effectiveness of the drug;
• Skin with a disturbed acid-base balance has an increased risk of an allergic reaction to the ointment;
• The towel, after wiping, must be disinfected, for example, boiled.

The medicine is applied 2-3 times a day, based on: a column of ointment, half a centimeter in size, on a skin area the size of a palm. It is also recommended to treat 1 cm of healthy skin around the affected area to prevent the spread of infection.

Treatment of thrush

Thrush (candidiasis) is a disease caused by pathogenic yeasts of the genus Candida. Usually occurs in the genital form, causes itching, more often in women and less often in men. sometimes it can affect other mucous membranes, such as the oral cavity. Clotrimazole is often prescribed for the treatment of thrush.

The use of Clotrimazole in female thrush:

• It is necessary to take a supine position, bend your knees, and inject a sufficient amount of the drug into the affected organ;
• For convenience, it is recommended to use a special applicator;
• Then, you need to lie down for at least half an hour so that the product is evenly distributed and absorbed;
• It is also necessary to process the external genitalia;
• To avoid stains on clothes, you can use panty liners, without fragrances;
• Since the ointment is poorly distributed over the surface of the skin, in the case of vaginal candidiasis, it is preferable to use other forms of the drug, such as cream or suppositories;
• The duration of treatment is up to one month.

The use of Clotrimazole for male thrush (candidal balanoposthitis):

If one of the sexual partners has thrush, treatment should be carried out in both. Even if one of them does not have visible symptoms of the disease, preventive therapy is prescribed.

Treatment of nail fungus and feet

• Apply the ointment not only to the foci of infection, but also to the skin of the finger;
• Rub gently;
• After applying the medicine in the area of ​​​​the feet, you can wear socks made of natural fabric - cotton or linen;
• In order to avoid a new infection, it is recommended to treat the inner surface of the shoe with Clotrimazole;
• , special solutions of the drug are more suitable, because interact with the nail plates better than ointment;
• Nails, in case of illness, need to be cut short, and the drug is better absorbed if they have a rough surface;
• Usually, to cure this form of fungus, you need a course of Clotrimazole, lasting from 4 to 8 weeks + 1 week of prevention.

Lichen treatment

The drug is suitable for:

• multi-colored (pityriasis) lichen;
• ringworm.

How to apply:

Treatment of dermatitis

It can be caused by both fungal infections and other causes.

There are three forms of this disease in which clotrimazole is often prescribed:

• seborrheic;
• atopic;
• diaper.

Application for seborrheic dermatitis

causes a fungus of the genus Malasesia, and treatment with antifungal agents is indicated here in any case.

Clotrimazole is used for seborrheic dermatitis on the face 3 times a day, on the head - 2 times a day.

For children, it is enough to apply the medicine once a day.

Use in atopic dermatitis

is an allergic disease, but can also be complicated by a fungus as a result of infection when scratching the skin.

Clotrimazole, in this case, is well suited, because. has additional antibacterial properties.

Usually prescribed in combination with other drugs.

For diaper dermatitis

Diaper dermatitis is an irritation of the skin in babies as a result of wearing diapers or constant swaddling, as the dense fabric does not breathe well and causes sweating.

May be complicated by candidiasis, as the fungus loves a moist, warm environment.

Usually the disease disappears after a week of applying the ointment. The ointment has low absorption, so its overdose is almost impossible.

It is desirable after the procedure that the baby has a glare for at least 10 minutes.

It is possible to prescribe additional drugs of different effects, depending on the specifics of the disease.

Use during pregnancy and lactation

Clotrimazole is not used in the first trimester of pregnancy. During the second and third trimester, the use of the drug is possible, with the permission of the doctor.

During lactation, you can not apply the medicine directly to the nursing breast.

Application in childhood

The drug can be prescribed to children, even newborns. For example, with diaper fungal dermatitis.

But with some restrictions:

• The skin of a child is involved in the process of breathing more actively than that of an adult, therefore it is not recommended to apply the medicine to large areas of the skin;
• Large foci of infection are treated in parts, alternately, 2-3 times a day;
• The ointment is suitable only for those types of fungal infection that are accompanied by drying of the skin.

For infected diaper rash in infants, Clotrimazole is used in the form of powders.

Contraindications

There are several contraindications:

• Hypersensitivity to the components of the drug;
• First trimester of pregnancy;
• The presence of wounds and abrasions on the skin;
• The presence of erosions of the mucous membranes;
• Intravaginal use during menstruation is unacceptable.

Side effects

In rare cases, the drug can cause:

• burning;
• tingling in treated areas;
• edema;
• erythema;
• redness;
• peeling of the skin.

In such cases, the drug is canceled.

special instructions

• Clotrimazole is not used for fungal eye diseases;
• Do not apply ointment to the skin around the eyelids;
• In case of contact with eyes, rinse with water;
• After applying Clotrimazole, occlusive dressings should not be applied;
• If after 3 days of treatment with the drug no improvement is observed, the correctness of the diagnosis should be checked;
• In liver failure, it is necessary to monitor the work of the liver;
• Clotrimazole preparations are not intended for internal use;
• May cause poisoning if swallowed. In such cases, one must take Activated carbon and see a doctor;
• After using the drug, wash your hands with soap;
• Keep away from children.

Overdose

The use of ointment in high doses does not pose a danger to life.

Interaction and incompatibility with other drugs

Simultaneous use of the drug with Amphotericin B, Nystatin, Nitamycin is unacceptable. they reduce the effectiveness of clotrimazole.

Terms and conditions of storage

In a dry, dark place at a temperature of 15 to 25 degrees Celsius.

Avoid freezing. Store in a place protected from children.

Price

The average price of Clotrimazole ointment in Russia: 42 rubles .

Clotrimazole ointment can rightfully be called a universal drug for fungal infection.

His wide range action allows you to act on various types of fungal pathogens, including those that affect the scalp or genital area. This drug has been on the pharmaceutical market for a long time, it is produced by various domestic and foreign manufacturers, has an affordable price, a lot of structural analogues, and can be used in combination with other pharmacy drugs.

On this page you will find all information about Clotrimazole: complete instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Clotrimazole ointment. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antifungal drug for external use.

Terms of dispensing from pharmacies

Released without a prescription.

Prices

How much does clotrimazole ointment cost? The average price in pharmacies is at the level of 47 rubles.

Release form and composition

Clotrimazole ointment has a white or almost white color, a homogeneous structure and a dense consistency. The main active ingredient of the drug is clotrimazole, its content in 1 g of ointment is 10 mg.

Auxiliary components of the ointment are:

• Methyl parahydroxybenzoate.
• Polyethylene oxide 1500.
• propylene glycol.
• Methylparaben.

It is in an aluminum tube in the amount of 30 g. The cardboard pack contains one aluminum tube with ointment and instructions for using the drug.

Pharmacological effect

Clotrimazole is a drug with a pronounced antifungal property, which refers to an imidazole derivative. The use of the drug allows you to inhibit the synthesis of ergosterol, thereby disrupting the permeability of fungal cells, causing their death. Clotrimazole - the active component of the ointment is effective against dermatophytes, yeast, mold fungi, has an antibacterial effect in staphylococcal, streptococcal infections. You can use this drug for various diseases of a fungal nature.

After application to the skin, the active ingredient is quickly absorbed into the upper and deep layers of the epidermis, practically does not penetrate into the bloodstream. A feature of the drug is the fact that after use the therapeutic effect will not be noticeable immediately, but after a while. However, with prolonged use, the effect of the drug will be 100%. It is very important in the process of using the ointment to observe skin hygiene, and also not to skip its use.

This ointment not only allows you to get rid of a fungal infection, but also significantly reduces skin infection with other bacteria, which often complicate the treatment process and the course of the disease.

Indications for use

What helps? Clotrimazole ointment has an antifungal effect, but it can not only kill the fungus - active substances have a detrimental effect on other pathogens that negatively affect the general state of human health.

Indications for the appointment of Clotrimazole ointment are:

• paronychia;
• combined infection candidiasis + trichomoniasis;
• dermatophytosis and other fungal infections.

Often this ointment is prescribed for treatment - the fungi that cause this disease are very sensitive to the main active ingredient of the remedy and therefore are destroyed relatively quickly. Medicine knows cases when Clotrimazole ointment helped to get rid of severe pigmentation, despite the fact that it is an exclusively antifungal agent.

The drug in question does a good job with both.

Contraindications

Allergic reactions or hypersensitivity to the active substance of the drug or to its other components, the menstrual period (with vaginal use).

Children can be from 2 years old.

Instructions for use

The instructions for use indicate that Clotrimazole Ointment for external use is applied to clean, affected areas of the skin with a thin layer several times a day, gently rubbing. The duration of treatment depends on the location, severity of the disease and the effectiveness of therapy:

1. Dermatomycosis is treated for at least a month;
2. Pityriasis versicolor - up to three weeks;
3. Fungal diseases of the skin of the legs - therapy is continued for at least two weeks after the symptoms have passed.

Clotrimazole cream can also be used to treat these diseases.

After applying Clotrimazole ointment, sealing dressings should not be applied.

Side effects

With external use of Clotrimazole ointment, edema may occur, as well as burning, peeling or skin irritation, itching, erythematous rashes, paresthesia, blistering or urticaria.

Overdose

To date, cases of overdose with Clotrimazole ointment have not been reported.

special instructions

1. It is not recommended to apply the drug to the skin in the eye area.
2. If there is no effect within 3 days, the diagnosis should be confirmed.
3. If signs of hypersensitivity or irritation appear, treatment is stopped.
4. In patients with hepatic insufficiency, the functional state of the liver should be periodically monitored.

drug interaction

Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole with simultaneous use.

When using the ointment, negative interactions with other agents are unknown and should not be expected, because. the resorption capacity of clotrimazole is very low.

Reviews

We picked up some reviews of people who used Clotrimazole ointment:

1. Natasha. For more than 20 years now, spots similar to a fungus have appeared on my neck periodically (4 months - half a year). I consulted a doctor, she prescribed Exifin ointment for me. I'll take a course of treatment - everything seems to pass. After 4-5 months it appears again. I smear again. And then she told me about her problem in a pharmacy, they advised me to kill the fungus from the inside, offering a Flucanazole capsule. She drank, three months later she drank another ode, to be sure. And nothing happened! Well, what kind of rubbish is sitting in me that nothing beats her? Here I want to try Clotrimazole ointment. According to rumors, the ointment is not bad. I hope it helps!
2. Kate . Clotrimazole treated nail fungus. Got it during pregnancy. Periodically rubbed the ointment into the nail and cut off the affected area. I smeared it a total of 10 times. Six months later, a healthy nail grew back.
3. Zoya. I was very surprised when on the third day the fingers became as good as new, but the sole passes more slowly. Before that, everything folk remedies I tried it and later it only got worse. The growths became thick, rough yellow, and even worse, they began to crack and it became painful to step on the sole until it bled. And thunder struck, I turned to the Internet and read about the drug CLOTRIMAZOL ointment there, there were others, but it seemed to me that it was of a wider spectrum and was very surprised that it costs 30 rubles. Most importantly, after that I believed in medicine and I will definitely go to the hospital to clarify diagnosis and cure. Of course, I didn’t descend from the mountains and medicine even saved my life more than once, but how do we think small troubles in the form of small cracks on the foot are nonsense, we will cure ourselves, but it wasn’t there, it was a fungus. I’m writing for everyone who will read, don’t pull do not waste time on random advice, they are all good only for prevention, but if the fungus has already appeared, run to the doctor. Well, this drug caught my eye and it helped me.
4. Margarita. I suffered for a long time with ringworm, I tried almost all possible means traditional medicine(laundry soap, soda, iodine, herbs) and expensive medicines. The doctor prescribed a very cheap cream Clotrimazole for treatment. I was very surprised - after the first week of application, the skin began to smooth out, and after three weeks everything was gone.

Analogues

Does Clotrimazole ointment have analogues? Certainly. They can be divided into two groups: with an identical active ingredient and with a different one. The first group includes:

• Amyclone;
• Candide;
• Candide - B;
• Candibene;
• Kanesten;
• Canison;
• Imidil.

Like Clotrimazole, the listed drugs have other forms of release, in addition to the cream.

The following ointments can be attributed to the second group:

• Pimafucin (active ingredient natamycin);
• Lamisil (terbinafine);
• Terbisil (terbinafine);
• Fungoterbin (terbinafine);
• Fucis (fluconazole) and other analogues.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The shelf life of Clotrimazole ointment is 2 years from the date of its manufacture.

The drug must be stored out of the reach of children at an air temperature not exceeding +20º C. Do not allow the ointment to freeze.

The drug with a pronounced antifungal effect is Clotrimazole. Instructions for use indicate that suppositories, vaginal tablets, ointment, cream, gel and 1% solution are widely used in gynecology. Patient reviews and doctors' recommendations report that this drug helps in the treatment of thrush (candidiasis) and other fungal and genital infections in men and women.

Release form and composition

Clotrimazole is produced in the forms:

• Vaginal tablets (candles Clotrimazole) containing 100 mg of the active substance - clotrimazole. 6 pieces in a blister.
• Antifungal ointment for external use. 1 g of ointment contains 10 mg of active ingredient. In tubes of 30 g.
• 1% cream Clotrimazole, applied externally, in tubes of 20 g.
• 2% vaginal cream, in tubes of 50 g; 1% solution for external use in orange bottles, 15 ml and 30 ml.

pharmachologic effect

Main active substance the drug produces an antifungal effect in relation to the following harmful bacteria:

• Sporothrix schenckii.

The drug has the highest penetrating power. Except antifungal action the drug produces antitrichomonas, antiamebic and antibacterial action.

What helps Clotrimazole (ointment, suppositories, cream, gel)?

Indications for the use of the drug include fungal diseases of the mucous membranes and skin and with mycosis of the skin folds and feet:

• Mycoses complicated by secondary pyoderma.
• Pityriasis versicolor.
• Microscopy.
• Dermatomycosis.
• Dermatophytosis.
• Epidermophytosis.
• Erythrasma.

Superficial candidiasis, the initiators of which are various types of fungi that are sensitive to clotrimazole.

• Candidiasis.
• Stomatitis.
• Genital infections and superinfections (in particular trichomoniasis and vulvovaginal candidiasis).
• Vaginal tablets (candles) are used to sanitize the birth canal before childbirth. Often, before operations on the genitals, suppositories are used as a preventive measure to prevent infection.

Instructions for use

Vaginal tablets Clotrimazole instructions for use prescribe to enter in the evening into the vagina as deeply as possible in the supine position with legs slightly bent, daily for 6 days, 1 vaginal tablet. A second course of treatment is possible after consulting a doctor.

In the presence of candidal vulvitis or candidal balanitis, it is recommended to simultaneously prescribe Clotrimazole in the form of a cream, applying it externally 2-3 times a day for 6-12 days to the affected areas.

Candles

For women and adolescent girls (after the onset of sexual activity), vaginal suppositories are administered in the evening into the vagina, as deep as possible, in the supine position with legs slightly bent, daily for 6 days, 1 vaginal suppository of 100 mg. A second course of treatment is possible after consulting a doctor.

Cream, ointment or gel

Apply a thin layer 2-3 times a day on previously cleansed (using soap with a neutral pH value) and dry affected skin areas and gently rub. The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy.

Treatment of ringworm is carried out for at least 4 weeks, pityriasis versicolor - 1-3 weeks. For fungal diseases of the skin of the legs, therapy is recommended to continue for at least 2 weeks after the symptoms of the disease have been eliminated.

Solution (can be used in adults and children). A few drops of the solution are applied in a thin layer to the cleansed and dry affected and surrounding skin areas 2 (morning and evening) and rubbed in thoroughly. After elimination of acute symptoms of the disease, treatment should be continued for an average of about 4 weeks.

With ringworm of the feet, the drug should be used for another 2 weeks after the elimination of all symptoms of the disease. It is recommended to use the solution after every foot wash.

Contraindications

The drug is not used for individual intolerance to its components. Also, the drug is not used to treat women in the first trimester of pregnancy. Extremely carefully and only according to medical indications, the drug can be used in the second or third trimesters of pregnancy and during breastfeeding.

Side effects

Allergic reactions.

When applied to the skin, the following are possible side effects:

• peeling;
• the appearance of blisters;
• burning;
• edema;
• skin irritation;
• erythema;
• tingling sensation.

Topical application for urogenital mycoses may be accompanied by burning, itching, swelling and hyperemia of the mucosa, intercurrent cystitis, vaginal discharge, increased urination, pain during intercourse.

When applied topically for mycoses oral cavity there may be redness of the mucous membrane, a tingling and burning sensation at the site of application of the drug, irritation.

Children, during pregnancy and lactation

The use of the drug during pregnancy is allowed only if, in the opinion of the doctor, the potential benefit of using the cream for the mother outweighs the possible risk to the fetus.

The use of Clotrimazole in women during breastfeeding is allowed only if, in the opinion of the doctor, the potential benefit of using the cream for the mother outweighs the possible risk to the child.

Applied externally in adults and children.

special instructions

To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary (can be used as a solution in men). With trichomoniasis for more successful treatment together with clotrimazole should be used other medicines with systemic action (for example, metronidazole inside).

drug interaction

During the use of vaginal suppositories, douching of the vagina is not recommended, as this may suppress the effect of Clotrimazole.

The drug should not be administered to patients simultaneously with Nystatin or Natamycin, since this drug interaction significantly reduces the therapeutic effect of the drug.

Clotrimazole's analogs

According to the structure, analogues are determined:

1. Kanesten.
2. Imidil.
3. Guinet-Lotrimin.
4. Clotrimazole-Acri.
5. Yenamazol.
6. Amiclon.
7. Candibene.
8. Lotrimin.
9. Faktodin.
10. Canison.
11. Antifungol.
12. Candizol.

Holiday conditions and price

The average price of Clotrimazole (vaginal tablets 100 mg No. 6) in Moscow is 24 rubles. The cost of an ointment or cream is 95 rubles. Released without a prescription.

Keep out of the reach of children at a temperature not exceeding +25 °C. Do not freeze. Shelf life - 3 years.

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In our time, no one is protected from such a scourge as a fungus; everyone, without exception, can catch this disease. Perhaps he already lives in your body, but the body's defenses successfully suppress its development.

However, with the slightest failure in immune system harmful microorganisms can become active and lead to unpleasant consequences. Clotrimazole ointment will help to quickly and painlessly say goodbye to the fungus. This effective remedy should be kept in every first aid kit.

The composition of the ointment Clotrimazole

The composition of this drug includes the active substance clotrimazole, which has antifungal properties, as well as the following auxiliary components:

• propylene glycol;
• polyethylene oxide 400;
• polyethylene oxide 1500;
• methyl parahydroxybenzoate or methyl paraben.

The drug must be stored at a temperature of +5 to + 25 ° C, in a dry place out of the reach of children.

What ointment helps from: indications for use

This antifungal agent treats the skin and mucous membranes. The active substances of Clotrimazole penetrate the fungal cell and inhibit its development. After using the drug, the harmful cell accumulates a lot of hydrogen peroxide, which leads to its destruction.

This tool not only kills the fungus, but also helps to cope with pathogenic bacteria that adversely affect human health. The drug is used to treat various diseases of the legs, mucous membranes, skin caused by fungi:

• thrush;
• genital candidiasis complicated by trichomoniasis;
• dermatomycosis;
• paronychia;
• dermatophytosis;
• erythrasma, etc.

Also, this remedy is recommended for infection with a fungus that provokes microsporia and. Fungi are especially sensitive to the main active substance, and therefore are destroyed quickly enough. However, you should prepare for the fact that the treatment will take more than one week.

In addition, the ointment helps to cope with such a problem as skin pigmentation. Of course, Clotrimazole is primarily an antifungal agent. But despite this, he helped many people get rid of age spots. Also, the drug is effective for streptoderma and herpes.

Analogues of Clotrimazole ointment:

• Candide;
• Kanesten;
• Amyclone;
• Candibene.

How to use Clotrimazole ointment

The method of use for many diseases is the same - the ointment is applied 3-4 times a day in a small dose on dry and clean skin or mucous membranes. Rub the drug into the affected areas carefully and carefully. It is impossible to cover the treated areas with bandages.

Often, doctors advise using the ointment in combination with other drugs. For example, with thrush, only complex treatment- with the use of ointment and vaginal suppositories.

The course of treatment with ointment can have a different duration, which depends on the form and stage of the disease. On average, you can focus on the fact that:

• Treatment of mycoses lasts at least a month. You can not interrupt the course even in the absence of visible signs of the disease. Sometimes doctors advise continuing to use the ointment for another 2-3 weeks after treatment for preventive purposes.
• Foot fungus must be treated for another two weeks after the symptoms have completely resolved.
• Lichen is treated for three weeks or more.
• Mild forms of thrush pass quite quickly - in 7-10 days.

How to use for thrush

Thrush is a common disease that affects both women and men. With candidiasis, it is recommended to use the ointment 2 times a day, treating the areas affected by the fungus with the agent.

Women should apply the ointment when the first symptoms appear, such as: itching and irritation in intimate places, a feeling of swelling, copious cheesy discharge, and burning when emptying the bladder.

With thrush, the vagina must be lubricated once a day with a thin layer of ointment, gently rubbing it in a circular motion. If the disease is chronic, then the drug should be applied not once, but three times a day. Approximate dosage - 5 gr. The duration of treatment is determined by the doctor. During the application of the ointment, you can not have sex. In the presence of the disease, both partners are treated. Clotrimazole for men is applied twice a day to the head and foreskin penis.

From nail and foot fungus

Small doses of Clotrimazole inhibit the development of mycosis, and large doses completely destroy it. Before proceeding to the use of the medication, it is necessary to wash the affected area with laundry soap and a solution of baking soda, and then dry it thoroughly.

The ointment must be applied in a thin layer on the affected areas 3 times a day. Treated areas must not be covered. After 5 days, you can notice the first signs of healing, but you should not interrupt the treatment. As a rule, treatment lasts 4-8 weeks. To make sure of your full recovery, you must pass the appropriate tests.

For the treatment of lichen

Clotrimazole ointment is used to treat pityriasis (color, multi-colored) lichen. This disease is caused by yeast. These microorganisms are opportunistic pathogens, i.e. they can live in the body of a healthy person, but do not cause any disturbance. However, certain factors can provoke uncontrolled reproduction of fungi, which will lead to the development of colored lichen.

With this disease, the ointment is applied to the affected areas 2-3 times a day for 2-4 weeks.

Can it be used during pregnancy and lactation

There is no evidence that the ointment can cause disturbances in the embryonic development of the fetus, however, the appropriateness of using this drug should be determined by the doctor on an individual basis. It is impossible to treat mammary glands with Clotrimazole during breastfeeding and lactation.

Contraindications and side effects

The ointment can not be used with increased sensitivity of the patient to its components and in the first three months of pregnancy. It is not recommended to apply the ointment for wet inflammations - in this case, it is better to resort to a cream with the same name, since it has drying properties.

With caution, the ointment is taken in the second and third trimester, as well as for problems with the liver.

Usually the drug is well tolerated by patients, but in some cases, side effects in the form of itching and irritation are possible. Swelling, peeling, redness may appear on the skin. In this case, the doctor determines the advisability of further use of the drug.

If an allergy in the form of urticaria appears on the skin after using Clotrimazole, then treatment should be immediately interrupted.

Antifungal drug for external use

Active substance

Release form, composition and packaging

◊ Cream for external use 1% in the form of a homogeneous mass of white.

Excipients: benzyl alcohol - 1 g, cetostearyl alcohol - 11.5 g, octyldodecanol - 10 g, polysorbate 60 - 1.5 g, sorbitan stearate - 2 g, synthetic spermaceti - 3 g, water - 71 g.

20 g - aluminum tubes (1) - packs of cardboard.

pharmachologic effect

Clotrimazole inhibits the growth and division of microorganisms and, depending on the concentration, may have a fungistatic (delaying and stopping the growth of fungal cells) or fungicidal (leading to the death of fungi) action. Clotrimazole inhibits the synthesis of ergosterol and binds to the phospholipids of the cell membrane of the fungus, which leads to a change in the permeability of cell membranes.

At higher concentrations, clotrimazole causes damage to cell membranes by mechanisms independent of sterol synthesis.

Clotrimazole also disrupts the vital processes in the fungal cell, inhibiting the formation of components necessary for building vital cellular structures (proteins, fats, DNA, polysaccharides), damages nucleic acids and increases potassium excretion.

Ultimately, the effect of clotrimazole on fungal cells leads to their death.

Clotrimazole is characterized by a wide spectrum antifungal and antibacterial activity: dermatophytes (Epidermophyton floccosum, Microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum), yeasts (Candida spp., Cryptococcus neoformans), dimorphic fungi (Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis), protozoa (Trichomonas vaginalis).

He also active against some gram-positive bacteria.

When studying the effectiveness of clotrimazole in laboratory conditions outside the human body (in vitro), a wide range of its fungistatic and fungicidal activity was revealed. It acts on the mycelium of dermatophytes (Trichophyton, Microsporum, Epidermophyton) similarly to griseofulvin, and its effect on budding fungi (Candida) is similar to that of polyenes (amphotericin B and nystatin).

At concentrations less than 1 μg / ml, clotrimazole inhibits the development of most strains of pathogenic fungi related to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis.

At a concentration of 3 μg / ml, clotrimazole inhibits the development of most other bacteria: Pityrosporum orbiculare, Aspergillus fumigatus, Candida genus, incl. Candida albicans, some strains of Staphylococcus aureus, Streptococcus pyogenes, and some strains of Proteus vulgaris and Salmonella. Clotrimazole is active against Sporothrix, Cryptococcus, Cephalosporium, Fusarium.

At concentrations greater than 100 µg/ml, it is effective against Trichomonas vaginalis.

Mushrooms resistant to clotrimazole are extremely rare; there are data only for individual strains of Candida guilliermondii.

No resistance development has been reported in clotrimazole-sensitive fungi after passage of Candida albicans and Trichophyton mentagrophytes. No cases of development of resistance to clotrimazole in strains of Candida albicans resistant to polyene antibiotics due to a chemical mutation have been described.

Pharmacokinetics

Suction and distribution

Pharmacokinetic studies have shown that clotrimazole is practically not absorbed into the systemic circulation when the drug is applied to intact or inflamed skin. Serum concentrations of clotrimazole were below the detection limit (0.001 µg/mL), confirming that topical clotrimazole does not cause clinically significant systemic effects or side effects.

Metabolism and excretion

Clotrimazole breaks down in the liver to inactive substances excreted from the body through the kidneys and intestines.

Indications

For external treatment of fungal infections caused by dermatophytes, yeast-like fungi, mold fungi, as well as pathogens sensitive to clotrimazole:

• mycoses of the feet, hands, trunk, skin folds;
• candidal vulvitis, candidal balanitis;
• versicolor versicolor, erythrasma;
• fungal infections of the external ear.

Contraindications

• hypersensitivity to clotrimazole or other components of the drug.

Dosage

For outdoor use. The cream should be applied to the affected areas of the skin 2-3 times / day.

For relapse prevention treatment should be continued for at least two weeks after the disappearance of all symptoms of infection.

The cream should be applied to clean, dry areas of the affected skin (washed with neutral pH soap), on the feet, the cream should be applied between the toes.

The duration of treatment depends on the severity of the disease, its localization, and the effectiveness of treatment.

Duration of treatment: ringworm - 3-4 weeks; erythrasma - 2-4 weeks; multi-colored lichen - 1-3 weeks; candidal vulvitis and balanitis - 1-2 weeks.

The duration of treatment may vary according to individual characteristics, but a duration of treatment of less than 3 weeks is not recommended. To prevent recurrence of infection, you should continue using the drug for 1-2 weeks after the disappearance of all symptoms of the disease. If after 7 days of treatment there is no improvement in symptoms, it is necessary to consult a doctor.

Side effects

The adverse events presented below are listed according to the damage to organs and organ systems and the frequency of occurrence. The frequency of occurrence is defined as follows: very often (≥1/10), often (≥1/100 and< 1/10), нечасто (≥1/1000 и < 1/100), редко (≥1/10 000 и < 1/1 000), очень редко (< 1/10 000, включая отдельные случаи), неизвестно (частота не может быть оценена по имеющимся на настоящий момент данным). Категории частоты были сформированы на основании пострегистрационного наблюдения.

From the immune system: unknown - an allergic reaction (manifested by urticaria, fainting, arterial hypotension, shortness of breath).

From the skin and subcutaneous tissues: unknown - rash, itching, blisters, peeling, pain or discomfort, swelling, burning, irritation.

Overdose

Symptoms: in case of accidental ingestion of the drug, nausea, vomiting may occur.

Treatment: in case of accidental ingestion of the cream, symptomatic treatment should be carried out. With external use of the drug, an overdose is unlikely.

drug interaction

Not studied.

special instructions

It is necessary to avoid getting the cream on the mucous membrane of the eyes. Do not swallow.

All infected areas should be treated at the same time.

The composition of the drug Clotrimazole includes cetostearyl alcohol, which can cause local skin reactions (for example, contact).

If symptoms of hypersensitivity or irritation appear, treatment is stopped.

Laboratory data indicate that the use of contraceptives containing latex can cause damage when used together with clotrimazole. Therefore, the effectiveness of such contraceptives may decrease. Patients should be advised to use alternative methods for at least 5 days after clotrimazole use.

Influence on the ability to drive vehicles and control mechanisms

No effect of clotrimazole on the ability to drive has been reported. vehicles and mechanisms.

Pregnancy and lactation

The use of the drug Clotrimazole with is allowed only if, in the opinion of the doctor, the potential benefit of using the cream for the mother outweighs the possible risk to the fetus.

In the conducted epidemiological studies, there were no adverse events in relation to pregnancy or fetal health when using the drug Clotrimazole.

The use of the drug Clotrimazole in women during breastfeeding is allowed only if, in the opinion of the doctor, the potential benefit of using the cream for the mother outweighs the possible risk to the child.

Fertility

No data available.

Terms of dispensing from pharmacies

The drug is released without a prescription.

Terms and conditions of storage

The drug should be kept out of the reach of children at a temperature not exceeding 25 ° C. Do not freeze. Shelf life - 3 years.